Compound X. An intermediate in enzymatic halogenation.

Structural Perspective on Enzymatic Halogenation

Simple halogen substituents frequently afford key structural features that account for the potency and selectivity of natural products, including antibiotics and hormones. For example, when a single chlorine atom on the antibiotic vancomycin is replaced by hydrogen, the resulting antibacterial activity decreases by up to 70% ( Harris , C. M. ; Kannan , R. ; Kopecka , H. ; Harris , T. M. J. Am. ...

Insights into enzymatic halogenation from computational studies

The halogenases are a group of enzymes that have only come to the fore over the last 10 years thanks to the discovery and characterization of several novel representatives. They have revealed the fascinating variety of distinct chemical mechanisms that nature utilizes to activate halogens and introduce them into organic substrates. Computational studies using a range of approaches have already ...

Organophosphorus Compound Induced 'Intermediate Syndrome'

Mechanism of the inhibition of enzymatic halogenation by antithyroid agents.

Identification of Intermediate Compound in Photodegradation of 1-Naphthol by WO3-rGO Nanocomposites

In this report, the degradation of 1-Naphthol was studied under xenon irradiation for 2 h using    WO3-rGO nanocomposite as photocatalyst. Raman spectroscopy and scanning electron microscopy demonstrated nanocomposite formation. Gas chromatography-mass spectrometry (GC-MS) technique which was utilized to analyze the degradation products, confirmed the formation of salicylic acid as a...